De elektronische studiegids voor het academiejaar 2025 - 2026 is onder voorbehoud.





Molecular developmental biology (3999)

  
Coordinating lecturer :Prof. dr. Nelly SAENEN 
  
Co-lecturer :Prof. dr. Karen SMEETS 
 Prof. dr. Michelle PLUSQUIN 
  
With assistance :Mevrouw Natascha STEFFANIE 
  
Member of the teaching team :Mevrouw Charlotte SEGNANA 
 dr. Karolien BIJNENS 
 De heer Martijn HELEVEN 


Language of instruction : English


Credits: 3,0
  
Period: semester 2 (3sp)
  
2nd Chance Exam1: Yes
  
Final grade2: Numerical
 
Exam contract: not possible


 
Sequentiality
 
   Mandatory sequentiality bound on the level of programme components
 
 
  Following programme components must have been included in your study programme in a previous education period
    Biology of the Cell (3370) 5.0 stptn
    Genetics, Evolution and the Tree of Life (2921) 7.0 stptn
    Molecular genetics (3726) .0 stptn
 
   Advising sequentiality bound on the level of programme components
 
 
  Following programme components are advised to also be included in your study programme up till now.
    Basic and practic skills in Chemistry (3461) 10.0 stptn
    Communication Skills (3118) 3.0 stptn
    Laboratory skills (2918) 3.0 stptn
 

Prerequisites
  • The student knows the different biomolecules and organelles and structures of the cell.
  • The student can explain the processes of translation, transcription, epigenetics and molecular regulation in detail.
  • The student has a basic knowledge about mammalian anatomy and structures.
  • The student has acquired specific laboratory skills, including the correct use of pipets, the calculation of dilution series, working in an structured manner and is able to save, manipulate and analyse data in Excel.


Content

Life cycles and developmental patterns; Principles of experimental embryology; Genes, development and genomic equivalence; Cell cell communication in development: signaling pathways; Early development of vertebrates; Gastrulation and axis formation; Heart development; Adult development and regeneration

Course specific learning outcomes: 
The student can recognize, name, describe, and schematically represent anatomical and cellular structures, organs, and tissues related to the embryonic development process.
The student can explain in detail the various phases of the embryonic development and regeneration process and relate them to relevant anatomical and cellular structures.
The student can identify, elaborate on, and reason about the key molecular players and pathways in the embryonic development and regeneration process. Additionally, the student can link these to specific phases and structures in the developmental process.
The student can apply research methodologies used in developmental biology to interpret related research data.
The student can execute a predetermined protocol in the lab and analyze, process, and report the obtained results in the form of a scientific poster and adjust it based on received feedback.
The student can search for information on a developmental biology-related topic by consulting scientific sources and literature, summarize this information, present it orally, critically reflect on it, and form a well-founded opinion.



Organisational and teaching methods
Organisational methods  
Collective feedback moment  
Lecture  
Practical  
Project  
Response lecture  
Teaching methods  
Group work  
Presentation  
Report  


Evaluation

Period 2    Credits 3,00

Evaluation method
Written evaluaton during teaching periode20 %
Transfer of partial marks within the academic year
Report
Oral evaluation during teaching period20 %
Transfer of partial marks within the academic year
Presentation
Written exam60 %
Open questions
Evaluation conditions (participation and/or pass)
Conditions Attendance at all practica/presentation is required. Students must justify any absence. In case of force majeure, an ad hoc arrangement will be provided.
Consequences Unauthorised absence at one or more of the practica/presentation results in unauthorised absence as the final mark. A student who achieves a score lower than 8/20 on one (or more) parts of the evaluation will receive 'F - fail' as the final result. This final result is not tolerable. A student who scores at least 8/20 for all parts of the evaluation receives a score that is the weighted average of the different points. This final mark is tolerable. E.g., 8/20 + 16/20 = 12/20 (passed).

Second examination period

Evaluation second examination opportunity different from first examination opprt
No
Explanation (English)Only the written exam, which counts for 60%, can be retaken during the resit period.
 

Compulsory textbooks (bookshop)
 

Textbook 1:

Developmental Biology, Michael J. F. Barresi and Scott F. Gilbert, twelfth Edition, Sinauer Associates, Inc.

ISBN: 9781605358741

 

Recommended reading
 

Titel: Principles of Development
Auteur: Lewis Wolpert, Cheryll Tickle and Alfonso Martinez Arias
Editie: 5
Uitgever: OUP Oxford
ISBN: 9780198709886
Extra info: /

 

Recommended course material
 

Articles

  • Gilbert, SF, Bosch, TCG, Ledón-Rettig C. 2015. Eco-Evo-Devo: developmental symbiosis and developmental plasticity as evolutionary agents. Nature Reviews Genetics; 16, 611-622. doi:10.1038/nrg3982
  • Abouheif E, Favé MJ, Ibarrarán-Viniegra AS, Lesoway MP, Rafiqi AM, Rajakumar R. 2014. Eco-Evo-Devo: The Time Has Come. In: Landry C., Aubin-Horth N. (eds) Ecological Genomics. Advances in Experimental Medicine and Biology, vol 781. Springer, Dordrecht. ISBN: 9789400773462

Resources

  • Online resource: eMouse Atlas Project (EMAP), http://www.emouseatlas.org/emap/home.html


Learning outcomes
Bachelor of Chemistry
  •  EC 
  • EC 2: A graduate of the Bachelor of Chemistry programme has to that end an extensive knowledge of the main branches of Chemistry, is familiar with their logic and their scientific methodology, and can apply them in solving a chemical problem, in particular:

    - analytical chemistry

    - inorganic chemistry

    - physical and theoretical chemistry

    - organic chemistry

    - the principles of biochemistry and macromolecular chemistry

    - the living world on molecular, cellular, genetic and organismal level, as far as a graduate of the Bachelor of Chemistry programme for the option Biochemistry is concerned

    - elements of physical chemistry in the field of inorganic, organic and theoretical chemistry, as far as a graduate of the Bachelor of Chemistry programme for the option Material Chemistry and partly for the optien Education is concerned

  •  EC 
  • EC 3:A graduate of the Bachelor ofChemistry programme has knowledge ofand insight inrelated fields of science such as physics, biology, geology and engineering sciences. He or she is able to communicate adequately with representatives of these fields.

  •  EC 
  • EC 5: A graduate of the Bachelor of Chemistry programme is able tounderstand experiments, to independently carry them out and to report on them. Additionally, he or she is able to assess the risks and to apply adequate safety procedures.

  •  EC 
  • EC 7: A graduate of the Bachelor of Chemistry is able to independently and in a self-managing manner acquire knowledgeand insight inchemistry and related fields, which was not covered in the programme.

  •  EC 
  • EC 8: A graduate of the Bachelor of Chemistrytakes intoaccountthe necessity of the interdisciplinary and multidisciplinary approach in analyzing chemical and biochemical questions.

  •  EC 
  • EC 10: A graduate of the Bachelor of Chemistry is able to report and to present orally and in writing in Dutch and in English and to take an argumented point of view regarding a topic from his/her discipline. He or she is able to communicate with colleagues and non-colleagues.

  •  EC 
  • EC 12: A graduate of the Bachelor of Chemistry programme is able to work in a constructive and project based manner with others as part of a team.

 

  EC = learning outcomes      DC = partial outcomes      BC = evaluation criteria  
Offered inTolerance3
3rd year Bachelor of Chemistry package free choice addition J



1   Education, Examination and Legal Position Regulations art.12.2, section 2.
2   Education, Examination and Legal Position Regulations art.15.1, section 3.
3   Education, Examination and Legal Position Regulations art.16.9, section 2.