De elektronische studiegids voor het academiejaar 2025 - 2026 is onder voorbehoud.





Drug delivery, pharmacology & toxicology (5524)
  
Coordinating lecturer :Prof. dr. Nelly SAENEN 
  
Co-lecturer :Prof. dr. Karen SMEETS 
  
Member of the teaching team :dr. Karolien BIJNENS 
 Prof. dr. Kurt VAN DER SPEETEN 
 Mevrouw Margo WITTERS 
 dr. Rik VERDONCK 

Language of instruction : English
Credits: 4,0
  
Period: quarter 4 (4sp)
  
2nd Chance Exam1: Yes
  
Final grade2: Numerical
 
Exam contract: not possible
 
Sequentiality
 
   No sequentiality

Content

Course content:

  • Introduction to “Drug delivery, Pharmacology, and Toxicology”
  • PART 1: From basic to controlled drug delivery
    • Pharmacokinetics of drugs
    • Drug delivery systems: from basic to controlled
    • Toxicity tests
  • PART 2: Advanced drug delivery
    • Targeting strategies and its clinical applications
    • Barriers to overcome
    • Toxicity of ‘new emerging compounds'
  • PART 3: Preclinical Validation
    • Preclinical validation using case studies

Learning goals:

  • The student has insight in the pharmacokinetics of drugs
  • The student can explain different drug delivery systems typically used for drug delivery, including controlled release
  • The student can explain active and passive targeting drug delivery and has insight in its potential applications
  • The student has insight in (particle) toxicity of drug delivery systems and how to take this into account in validation studies
  • The student has insight in the trajectory of validation studies and can relate the interplay between research and clinical phases (MHD/KBW/Elective course)


Organisational and teaching methods
Organisational methods  
Lecture ✔  
Project ✔  
Small group session ✔  
Tutorial group ✔  
Teaching methods  
Discussion/debate ✔  
Group work ✔  
Presentation ✔  


Evaluation

Period 4    Credits 4,00

Evaluation method
Oral evaluation during teaching period30 %
Transfer of partial marks within the academic year✔
Presentation✔
Written exam70 %
Open questions✔
Evaluation conditions (participation and/or pass)✔
Conditions Presence at the Journal clubs and assignment(s) is obligatory. The evaluations consist of multiple parts. For all parts of the evaluation, at least a score of 8/20 must be obtained in order to pass the course.
Consequences Students who are unjustifiably absent from the journal club or assignment presentation receive an N-unjustified absence as a final grade for the course and have to attend the missed journal club/assignment in the next academic year to receive their final grade. The student needs to re-enrol in the course in the next academic year. In this case, partial grades can be transferred to the next academic year. A student who achieves a score lower than 8/20 on one (or more) parts of the evaluation will receive 'F - fail' as the final result. This final result is not tolerable. A student who scores at least 8/20 for all parts of the evaluation receives a score that is the weighted average of the different points. This final mark is tolerable. E.g., 8/20 + 16/20 = 12/20 (passed).

Second examination period

Evaluation second examination opportunity different from first examination opprt
No
 

Compulsory course material
 

All lecture materials will be available on blackboard.


Learning outcomes
Master of Biomedical Sciences
  •  EC 

    • 1. A graduate of the Master of Biomedical Sciences has a thorough knowledge of the molecular and cellular processes of the healthy and diseased organism and has insight in different methods for prevention, diagnosis and therapy of diseases.

  •  EC 

    • 10. A graduate of the Master of Biomedical Sciences knows the potential for valorization of biomedical research and can translate own research into translational research.

  •  EC 

    • 12. A graduate of the Master of Biomedical Sciences has an attitude for lifelong learning and for constantly adjusting one's own professional thinking and acting. 

  •  EC 

    • 2. A graduate of the Master of Biomedical Sciences can independently and critically perform a literature search

  •  EC 

    • 4. A graduate of the Master of Biomedical Sciences has knowledge of state-of-the-art techniques within biomedical research and is able to apply these techniques, taking into account the applicable quality standards.

  •  EC 

    • 7. A graduate of the Master of Biomedical Sciences takes a critical attitude towards one's own research and that of others.

 
Master of Biomedical Sciences
  •  EC 

    • 1. A graduate of the Master of Biomedical Sciences has a thorough knowledge of the molecular and cellular processes of the healthy and diseased organism and has insight in different methods for prevention, diagnosis and therapy of diseases.

  •  EC 

    • 10. A graduate of the Master of Biomedical Sciences  knows the potential for valorization of biomedical research and can translate own research into translational research. 

  •  EC 

    • 12. A graduate of the Master of Biomedical Sciences has an attitude for lifelong learning and for constantly adjusting one's own professional thinking and acting.

  •  EC 

    • 2. A graduate of the Master of Biomedical Sciences can independently and critically perform a literature search.

  •  EC 

    • 3. A graduate of the Master of Biomedical Sciences can draw up a new research hypothesis based on his or her own findings or based on the findings of others, and work out a research proposal for this.

  •  EC 

    • 4. A graduate of the Master of Biomedical Sciences has knowledge of state-of-the-art techniques within biomedical research and is able to apply these techniques, taking into account the applicable quality standards.

  •  EC 

    • 7. A graduate of the Master of Biomedical Sciences takes a critical attitude towards one's own research and that of others.   

 
Master of Teaching in Health Sciences
  •  EC 

    • 5.1 The educational master is a domain expert HEALTH SCIENCES: the EM has an understanding of the construction and functioning of the human body in disease and health (at the molecular, cellular, organ and organism level).

 
  EC = learning outcomes      DC = partial outcomes      BC = evaluation criteria  
Offered inTolerance3
1st year Master of Biomedical Sciences - Bioelectronics and Nanotechnology J
1st year Master of Biomedical Sciences - Molecular Mechanisms in Health and Disease J
first year Master of Biomedical Sciences - Clinical Biomedical Sciences J
Master of Teaching in Health Sciences keuzetraject BMW/GEN met vakdidactiek biologie J
Master of Teaching in Health Sciences keuzetraject BMW/GEN met vakdidactiek chemie J



1   Education, Examination and Legal Position Regulations art.12.2, section 2.
2   Education, Examination and Legal Position Regulations art.15.1, section 3.
3   Education, Examination and Legal Position Regulations art.16.9, section 2.